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Article published February 6, 2018 on Medium by Barry Seifer
Founder | CEO Hearing Health Science
Tinnitus is a neurological disorder. Untreated hearing trauma and hearing loss causes tinnitus, the beep or ringing that seems to be in the ears. Tinnitus may start with damage to the ear, but persistent tinnitus actually originates in the brain.

Tinnitus can often start with exposure to high intensity noise, an environmental stress factor that causes damage which can lead to cell death.

High intensity noise can cause:
  • damage to micro-mechanical properties of sensory transducers (hair cells);
  • changes in blood flow in the ear;
  • modification in intracellular ion transport properties;
  • depletion of sensory cell transmitter substances (e.g. glutamate);
  • changes in post synaptic membrane transmitter receptors (e.g. gluR) on afferent nerve fibers (axons) of afferent neurons (sensory neurons);
  • modification of dispersion and uptake properties of neurotransmitters in extracellular, synaptic spaces;
  • changes in postsynaptic membrane biophysical properties that may affect space-and time-constant properties modifying depolarization;
  • changes of an excitotoxic nature in postsynaptic membranes causing destruction of afferent neural tissues.

Preserving hearing helps prevent tinnitus because the data say hearing loss associated with damage in the inner ear is responsible for about 80% of the cases of tinnitus. We set out to preserve hearing, not cure tinnitus. We make Soundbites. Soundbites is a safe, potent, multi-patented nutritional supplement comprised of antioxidants A, C, and E and the mineral Magnesium, together ACEMg (say “ACEMg”). ACEMg is Soundbites.

You can take Soundbites to preserve the hearing you have.

Case report evidence collected over the past several years suggests a correlation of ongoing use of Soundbites with reduced tinnitus symptoms. In fact, Soundbites holds an issued patent to prevent and treat tinnitus. You can read the patent here. We thought it might be useful to share our thinking about that.

We have two likely theories to explain how Soundbites might be working to treat chronic tinnitus (tinnitus that persists for a long time or constantly recurs).

Mostly we have focused on the Magnesium (Mg) component in the ACEMg formulation. Mg increases blood flow to the inner ear, removes waste and increases oxygenation of tissues, helping the cells of the inner ear to work at a higher level of efficiency generally.

With exposure to loud noise, blood flow to the inner ear decreases, resulting in less efficient cellular function that can lead to tinnitus. One theory is that by blocking the decrease in inner ear blood flow, Mg is preventing the decreased functionality and the resulting tinnitus.

Mg is also a calcium blocker. Loud sounds activate a high level of activity of hair cells (inner ear hearing cells), causing the hair cells to release an excess of the neurotransmitter glutamate at their base. The glutamate neurotransmitter activates the post membrane terminals of the neurons that transmit activity to the brain through long, slender axon nerve fiber projections of the nerve cell.

The opening of pores in the post membrane terminals allows excess calcium to flow into the terminals and with that water, which causes them to swell and sometimes to burst. The process is referred to as excitotoxicity. The temporary or permanent loss of localized bundles of auditory nerve fibers may cause the tinnitus that is associated with loud noise. In some cases, some auditory nerve fibers may repair with rest (no exposure to loud sounds). In other cases, they cannot.

Mg as a calcium blocking agent can prevent excitotoxicity, thus preventing the damage to auditory nerve fibers that causes tinnitus. It is thought that with chronic long term tinnitus the pathology moves to more central locations in the brain and may not be affected by this proposed Mg mechanism.

The antioxidant vitamin component in Soundbites (the “ACE” component) may play a significant supporting role in mitigating tinnitus. Excess free radicals can cause release of excess glutamate neurotransmitter. Since ACE eliminates free radicals and the subsequent release of excess glutamate, the vitamins may also be helping prevent excitotoxicity and attenuate tinnitus.

In addition, high noise or intense sound levels demand greater activity of the mitochondrial respiratory chain to create ATP . Greater demand for ATP results in excess free radical formation.

Typically in the normal ear under normal stress the endogenous antioxidant systems are sufficient to maintain normal homeostatic function of the inner ear, but under high levels of stress the increased free radical formation may contribute to excitotoxicity and will damage DNA and further, through the process of lipid peroxidation , destroy inner and extracellular membranes.

Any one or more of these changes can result in modification of spontaneous activity in individual or small populations of afferent nerve fibers, leading to temporary loss in hearing sensitivity, distortions of sounds, muffling of sounds, perception of tinnitus. and permanent hearing loss associated with cell death.

We are vitally interested using the Soundbites real world studies to assess Soundbites efficacy to reduce or prevent temporary and permanent tinnitus. That’s another story.

Hearing loss is a metabolic stress disorder. What does that mean?

Metabolic stress causes about ninety percent of permanent hearing loss, the same fundamental common cause of nutritional deficiency diseases. Hearing loss is now considered a disease by government health and drug agencies.

Metabolic stress is triggered by excess free radicals. Free radicals are oxygen molecules essential for metabolism. Metabolism is the complex series of biochemical reactions within cells that use food to create energy and maintain life.

Extra free radicals create oxidative stress that damages and ultimately causes the death of irreplaceable hearing cells. Oxidative stress plays the leading role in the development of hearing loss.

Antioxidant systems play a major role maintaining healthy metabolism. They eliminate excess free radicals to maintain healthy cell metabolism. Abnormally high levels of oxidative stress can compromise and overwhelm antioxidant systems.

Micronutrients are essential to maintain the body’s healthy antioxidant systems. We know malnutrition or insufficient nutrition from foods containing certain vitamins, minerals and proteins can compromise antioxidant systems and lead to metabolic disorders and nutritional deficiency disease. This is true for the inner ear as well. Compromised inner ear antioxidant systems lead to hearing loss.

Symptoms of metabolic disorders like hearing loss usually start when cell metabolism comes under free radical-induced metabolic stress.

Inner ear metabolic stress can be initiated externally by ongoing exposure to intense sound or noise, or internally by the ototoxic side effects of gentamicin aminoglycoside antibiotics and other drugs, or by genetic defect like Connexin 26, or by aging. The stress interferes with normal metabolism, constricting normal inner ear blood flow, leading to cell damage, cell death and permanent hearing loss.

Exposure to intense levels of sound or noise triggers massive overproduction of inner ear free radicals. The free radicals trigger the release of a powerful vasoconstrictor 8-iso prostaglandinF2a. Restricted blood flow traps excess free radicals and overwhelms inner ear antioxidant systems. Symptoms can be temporary or permanent, including “hard of hearing” — distorted or muffled hearing or reduced sensitivity to sound, or “beep in the ear” (tinnitus), or both.

The evidence is that the metabolic stress that causes hearing loss can be treated with Soundbites.

Metabolism depends on oxidation-reduction reactions using free radicals (the oxidants) neutralized by antioxidant systems. The metabolic system (cellular energy production) of smaller mammals — guinea pigs, rats, mice, for example — works the same way as humans.

Soundbites eliminates the excess free radicals that cause metabolic stress initiated by deficiency of antioxidant micronutrients in the inner ear of mammals.

The metabolic disorder is initiated by excess inner ear free radicals that cannot be neutralized by internal (endogenous) antioxidant systems. Soundbites provides extra (exogenous) antioxidants to inner ear cells to help them continue functioning normally when they are under stress from intense sound and noise.

Understanding the complexities of inner ear cell metabolism and the actions of micronutrients enabled the discovery of a new, safe way to avoid metabolic stress and preserve hearing. Inner ear metabolic disorders can be treated with a safe antioxidant micronutrient ‘cocktail’. Hearing Health Science founder, the late Dr. Josef M. (Joe) Miller developed the ACEMg solution in 2005 after a quarter century of research at the University of Michigan Medical School.

Many scholarly articles on free radicals research and the development of the ACEMg formula have been published in leading peer-reviewed academic journals. ACEMg is currently covered by eight patents, with one more pending. ACEMg is marketed to consumers as Soundbites, and as ACEMg Clinical Care to physicians.

Soundbites works in the inner ear when excess free radicals cause vasoconstriction and cell death. The formula i) protects cells from stress-induced damage; ii) maintains cellular integrity; iii) promotes normal cell function; iv) prolongs healthy life of hearing cells; v) preserves hearing that would otherwise occur from exposure to noise and in aging.

Soundbites stops free radicals from forming in the metabolic ‘power plant’ of the cell, called the mitochondrion. Soundbites provides pure antioxidant scavengers that grab free radicals as they’re formed, eliminating them before they can harm the inner ear. Soundbites provides extra Magnesium (Mg) preventing inner ear vasoconstriction and dilation, similar to what happens in strokes and heart attacks.

Vitamin E lives in and removes free radicals from the lipid part of the cell. Vitamin C lives in and removes free radicals from the water compartment of the cell. Beta-carotene, the precursor to Vitamin A, can live in either compartment of the cell, capturing free radicals that get away in either of the cell’s other two compartments. In these ways Soundbites protects against inner ear oxidative stress, helping hearing cells cope with excess energy demands originating in the environment or in devices.

Please keep in mind that Soundbites cannot be expected to restore hearing.
TRY SOUNDBITES FOR YOURSELF
The ACEMg micronutrient formula inside Soundbites has a positive influence on your health. Vitamin A plays a role in the process of cell specialization. Vitamin C and E contribute to the protection of cells from oxidative stress. Vitamins C and E are known as ‘free-radical catchers’.

These processes contribute to cell renewal and protect cells throughout the body, including your inner ear cells.

You can use Soundbites if you work in the music industry, are a regular music festival visitor, like to party, listen to music on a daily basis, or if you work in a noisy environment like a construction site.

We encourage earplugs and ear protection devices in addition to Soundbites whenever possible or practical.

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